【總結(jié)】作者通過定向冷凍PAAS/GO漿料，確表然后經(jīng)過冷凍干燥、酰亞胺化和2800℃石墨化，制備了各向異性的高質(zhì)量石墨烯氣凝膠。【研究亮點(diǎn)】1.通過定向冷凍聚酰胺酸鹽(PAAS)和氧化石墨烯(GO)的水懸浮液，亂收然后冷凍干燥、亂收酰亞胺化和石墨化來制備各向異性高質(zhì)量石墨烯氣凝膠(AGAs)。圖2.拉曼表征a)PG0，濟(jì)南價(jià)部b)PG2，c)PG4，d)PG6和e)PG8的拉曼圖。

首先，市物示收費(fèi)屬于隨著GO濃度的增加，孔結(jié)構(gòu)出現(xiàn)片層到蜂窩的轉(zhuǎn)變，然后，蜂窩孔的直徑減小。因此，門明內(nèi)部應(yīng)力產(chǎn)生并誘導(dǎo)高質(zhì)量石墨烯的產(chǎn)生。

有趣的是，確表隨著GO的加入，觀察到了層狀到管狀的轉(zhuǎn)變。

此外，亂收縱向PCC8中的溫度梯度在整個(gè)充電過程中更穩(wěn)定。濟(jì)南價(jià)部Related?referencesonthistopic:Jin-ZhiDu,Tian-MengSun,Wen-JingSong,JuanWu,JunWang*,ATumor-Acidity-ActivatedCharge-ConversionalNanogelasanIntelligentVehicleforPromotedTumoral-CellUptakeandDrugDelivery?Chem.Int.Ed.?2010,?49,3621–3626.Jin-ZhiDu,Xiao-JiaoDu,Cheng-QiongMao,JunWang*,Tailor-MadeDualpH-SensitivePolymer-DoxorubicinNanoparticlesforEfficientAnti-CancerDrugDeliveryAm.Chem.Soc.2011,?133,17560–17563.?Hong-JunLi#,Jin-ZhiDu#,Xiao-JiaoDu#,Cong-FeiXu,Chun-YangSun,Hong-XiaWang,Zhi-TingCao,Xian-ZhuYang,Yan-HuaZhu,ShumingNie*,JunWang*,Stimuli-ResponsiveClusteredNanoparticlesforImprovedTumorPenetrationandTherapeuticEfficacy?Natl.Acad.Sci.U.S.A.?2016,113,4164–4169.Hong-JunLi#,Jin-ZhiDu*,#,JingLiu,Xiao-JiaoDu,SongShen,Yan-HuaZhu,XiaoyanWang,XiaodongYe,ShumingNie*,JunWang*,SmartSuperstructureswithUltrahighpH-SensitivityforTargetingAcidicTumorMicroenvironment:InstantaneousSizeSwitchingandImprovedTumorPenetration,ACSNano?2016,10,6753–6761.SongShen#,Hong-JunLi#,Kai-GeChen,Yu-CaiWang,Xian-ZhuYang,Zhe-XiongLian,Jin-ZhiDu*,JunWang*,SpatialTargetingofTumor-AssociatedMacrophagesandTumorCellswithapH-SensitiveClusterNanocarrierforCancerChemoimmunotherapy,NanoLett.,2017,17,3822–3829.Xian-ZhuYang,Jin-ZhiDu,Cheng-QiongMao.ShuangDou,Hong-YanLong,JunWang*,SheddableNanoparticlesforTumor-AcidityTargetingSmallInterferingRNADeliveryACSNano?2012,6,771–781.?You-YongYuan,Chen-QiongMao,Xiao-JiaoDu,Jin-ZhiDu,FengWang,?JunWang*,SurfaceChargeSwitchableNanoparticlesBasedonZwitterionicPolymerforEnhancedDrugDeliverytoTumor?Mater.?2012,24,5476–5480.?Chun-YangSun#,YangLiu#,Jin-ZhiDu#,Zhi-TingCao,Cong-FeiXu,JunWang*FacileGenerationofTumorpH-LabileLinkage-BridgedBlockCopolymersforChemotherapeuticDelivery?Chem.Int.Ed.?2016,128,1010-1014.Chun-YangSun#,SongShen#,Cong-FeiXu,Hong-JunLi,YangLiu,Zhi-TingCao,Xian-ZhuYang,Jin-XingXia,JunWang*?TumorAcidity-SensitivePolymericVectorforActiveTargetedsiRNADeliveryAm.Chem.Soc.?2015,137,15217–15224.?Xian-ZhuYang#,Xiao-JiaoDu#,YangLiu,Yan-HuaZhu,Yang-ZhongLiu,Ya-PingLi,JunWang*?RationalDesignofPolyionComplexNanoparticlestoOvercomeCisplatinResistanceinCancerTherapy?Mater.?2014,26,931-936.?DongdongLi,YinchuMa,JinzhiDu,WeiTao,XiaojiaoDu,XianzhuYang*,JunWang*,TumorAcidity/NIRControlledInteractionofTransformableNanoparticlewithBiologicalSystemsforCancerTherapy,NanoLett.2017,17,2871–2878.。

2016年6月起任華南理工大學(xué)醫(yī)學(xué)院教授、市物示收費(fèi)屬于生命科學(xué)研究院及國家人體組織功能重建工程技術(shù)研究中心研究員。在早期的研究中，門明科學(xué)家過分注重提高納米粒子在腫瘤部位的富集，門明而忽略了納米藥物的療效很大程度上是由納米藥物從注射部位到作用部位所需要克服的傳遞障礙所決定的。

傳統(tǒng)的藥物傳遞體系雖然有一定的優(yōu)點(diǎn)，確表卻不能同時(shí)克服這些障礙。前期的研究證明，亂收尺寸較小的納米粒子比尺寸較大的納米粒子更容易穿透組織，但是尺寸較小的納米粒子在體內(nèi)很容易被清除。